People has honored them both as the Sexiest Man Alive.
Angelina Jolie has kissed each on his lips.
Fans across the globe have swooned in their wake... but the fun times are about to come to an end for Brad Pitt and Johnny Depp!
These hunks walked the red carpet at last night's NYC premiere of The Tourist and are matched up below in a THG Fashion Face-Off. After you check out the official promo for this movie, cast your vote in the challenging poll here: